圣多明各或圣多明哥,全名圣多明各德古斯曼,位于多米尼加共和国的国家特区内,为多米尼加的首都。它是多米尼加共和国的首都和最大城市,也是加勒比地区人口最大的都市区。截至2020年,城市人口约有1,049,567人,都会区总人口为4,210,121人,仅次于古巴的哈瓦那,是加勒比海地区人口第二多的城市,这座城市与 Distrito Nacional的边界相连,它本身与圣多明各省的三边接壤。 圣多明各是西班牙在美洲地区最早的殖民地,当前为是拉丁美洲经济最发达的城市之一,并拥有美洲最早的公路、大学、医院及教堂,该城市的旧城区则被列为世界文化遗产。
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