Activin RII phosphorylates Activin RI, which activates the Smad2/3 signaling pathway. The activated Smad2/3 transcription factors reach the nucleus and control the production of genes involved in ...

When just a single pathway is active (Wnt, lower left, Activin, lower right), only a few genes are turned on.

ARO-ALK7 is the first RNAi therapy targeting adipose tissues and is engineered to suppress the activin A receptor type ... receptor to intervene in a known pathway that signals the body to store ...