We have been exploring the potential of the neuromodulator, adenosine, to reduce excessive dopamine signaling that contributes to the development and persistence of psychostimulant abuse. Dopamine’s ...

To this end, radioreceptor and functional studies of these three compounds were conducted at each of the known molecular isoforms of the dopamine receptors in several transfection systems ...

Caffeine, on the other hand, affects the brain differently by blocking adenosine receptors, specifically A2A receptors, which play a role in moderating dopamine activity. By antagonizing A2A ...