Enzyme activity is tightly regulated in living organisms to maintain homeostasis and respond to changing conditions. Enzymes can be regulated by various means, such as allosteric regulation (binding ...

Owing to complete inhibition of enzyme activity ... with Phe196 in UCR2 are key for PDE4D selectivity. Although such allosteric modulators only partially inhibit PDE4 activity, they are still ...

Another current area of research for LLAB involves unraveling the mechanistic principles underlying positive allosteric modulators of lecithin-cholesterol acyltransferase (LCAT). LCAT is an enzyme ...

Its See-Tx target identification platform uses the published 3D structure of enzymes and a proprietary computational technology to discover new allosteric binding sites and predict their druggability.