A survey of single–amino acid substitutions found that substitutions closer to the active site give larger improvements in enantioselectivity or diastereoselectivity than substitutions further ...

Announcing a new article publication for Zoonoses journal. Zoonotic transmission of severe acute respiratory coronavirus 2 (SARS-CoV-2) has been found to result in infections in more than 30 mammalian ...

The final DAPDH variant contains five amino acid substitutions and achieves the goal of being useful for synthetic applications. It shows good activity and high enantioselectivity and now accepts ...

This pathway approach revealed that 1) 13 proteins were conserved, whereas five lacked data sufficient to determine specific critical amino acids; 2) variation in protein-protein interfaces is ...

Regulatory policies influence the availability of affordable biosimilars, with varying impacts across different jurisdictions ...