as folding simulations showed the need to mesh theory with experiment. Two major subjects, which are central to understanding the mechanism of protein folding, are not included here because of the ...

Protein folding is the physical process by which a protein chain is translated to its native ... The resulting three-dimensional structure is determined by the amino acid sequence or primary structure ...

Our goal is to design a new generation of proteins that address current day problems not faced during evolution. In contrast to traditional protein engineering efforts, which have focused on modifying ...

is required for the proper folding of many proteins under normal conditions in the living cell. The amino acid sequence determined the proper fold of these proteins, as inferred by Anfinsen, but a ...

Schematic representation of free energies before (a) and after (b) the linkage of folding and misfolding transitions. (a) A two-state transition independent of protein concentration persists.