F = factor, a = activated. Reproduced from reference 8, with permission. Interactions of anticoagulants with thrombin. Panel A shows heparin bound to thrombin at exosite 2 and to antithrombin III.

ref 39), antithrombin III, interferon-β, leukemia inhibitory factor and platelet factor 4. Naturally occurring angiogenesis inhibitors may be involved in tumor dormancy and are being tested for ...

Antithrombin ... be based on AT-III levels obtained 20 minutes post-infusion, every 12hrs, and before the next dose. Maintain AT-III levels at 80–120% of normal for 2–8 days.