Patients were randomly allocated to receive anastrozole 1 mg daily or placebo, in addition to their usual GH therapy, and were examined at 3-month intervals. Anastrozole treatment continued for 36 ...

The study was a multicentre, randomised, non-blinded, parallel-group trial of 0.5 and 1mg/day of anastrozole and approved by the Institutional Review Board in each of the 30 participating centres.