When the immune system malfunctions, there may be issues with the production and regulation of cytokines, leading to the development of autoimmune diseases. ACROBiosystems is providing you with a ...

Diane Mathis and Christophe Benoist describe how our understanding of the role of autoimmune regulator (AIRE) in central tolerance has developed over the past 10 years. Peripheral immune tolerance ...

Is it the authors' opinion that we largely rely on infectious agents to generate the regulatory B cells that contribute not only to recovery from exacerbation of autoimmune disease, but also to ...

AIRE gets its acronym from its role: autoimmune regulator gene—AIRE, which underlies a cascade of deleterious events. The most insidious of those events is the proliferation of a highly reactive ...

There were also biological signs of premature aging in the organ, and lower levels of a key autoimmune regulator. It shows ...

APS 1 is caused by mutations of the autoimmune regulator (AIRE) gene, which encodes an activator of transcription, Aire, that induces the expression of autoantigens in thymic medullary epithelial ...

Park JS; Jeong JH; Byun JK; Lim MA; Kim EK; Kim SM; Choi SY; Park SH; Min JK; Cho ML Regulator of calcineurin 3 (RCAN3), an endogenous regulator of the calcineurin-nuclear factor of activated T ...