The term 'autophagy' was chosen to distinguish the lysosomal degradation ... to analyse mammalian cells that express autophagy proteins tagged with fluorescent markers. Time-lapse studies provide ...

Several proteins that have an essential role in autophagy have a direct or indirect ... indicating that catalase degradation is strongly tied to cell death and depends on the upstream signal ...

A new study unravels the relationship between mitofusins (mitochondrial proteins) and autophagy. Using gene editing with CRISPR-Cas9, the team has been able to study these proteins without altering ...

Autophagy is the process by which cells digest and renew their internal structures, recycling damaged or malfunctioning ...

Professor Noboru Mizushima's research project is focusing on autophagy, and is trying to clarify various questions related to intracellular degradation. A common mechanism of eukaryotes, from yeast to ...

Intracellular constituents such as proteins and organelles are turned over by unremitting synthesis and degradation. This dynamic turnover is critical for homeostasis, development, and environmental ...

Autophagy, the cell’s essential 'housekeeping' process, involves degrading and recycling damaged organelles, proteins ... significance of autophagic degradation of the nucleus remains unknown.

They also discovered that the PI3K complex, an autophagy-related protein, is essential for ... a nutrient source through ...

Headed by Drs. Antonio Zorzano and Saska Ivanova, a study published in the journal Autophagy unravels the relationship between mitofusins (mitochondrial proteins) and autophagy. Using gene editing ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...

View Full Profile. Learn about our Editorial Policies. Guan and his team compared 171 genes that influence autophagy to study how they affect metastasis in a mouse model of breast cancer. By using ...