In February 2004, pemetrexed disodium (Alimta; Eli Lilly), an anticancer drug that targets folate-dependent reactions that are essential for cell proliferation, became the first drug to be ...

The coverage guidelines are as follows: Pemetrexed: One intramuscular injection of vitamin B12 before the first dose and then every three cycles. Pralatrexate: 1 (milligram) mg of vitamin B12 as ...