The protective proteins in our bodies aren’t just great for fending off infection—they could also fight the effects of ...

Notably, IFT20 clusters with TCRs at the immune synapse and associates with the ζ- and ɛ-chains of CD3 in response to TCR engagement.

Alzheimer’s disease represents an almost insurmountable global health challenge, affecting millions worldwide with few treatment options available. Tiziana’s novel approach focuses on reducing ...

Tiziana Life Sciences ( (TLSA) ) has shared an update.

In a presentation titled "Building Multispecifics from in vivo Derived Antibody Domains and Alternative Scaffolds," Yasmina Abdiche, Ph.D., Vice President of Exploratory Research, provided an overview ...

Medigene announces KRAS G12V as first target for TCR-guided T cell engagers: Planegg, Germany Tuesday, December 10, 2024, 17:00 Hrs [IST] Medigene AG, an oncology platform company ...

The selection of this first target is a key step for the partnership between Medigene and WuXi Biologics, which aims to advance multiple TCR-TCEs over the next three years. The collaboration seeks to ...

iBio, Inc, a preclinical stage biotechnology company, engages in the development of artificial intelligence (AI) antibodies solutions for cancer, and other diseases. The company’s technology platforms ...

Earlier this year, Crossbow Therapeutics Inc. announced the nomination of its first development candidate, CBX-250, a TCR-mimetic (TCRm) bispecific T-cell engager (TCE) antibody targeting a CTSG ...

The double-headed antibody binds to CD3 on T cells and redirects them to BCMA-expressing myeloma cells, with the aim of stimulating an immune attack on the tumour, which remains incurable despite ...

As the induction of Tregs is not dependent on the CD28-B7 pathway, [45] combination therapy of anti-CD3 antibody therapy and abatacept or other costimulatory blockade molecules might be complementary.