The CD34+CD38− cells, isolated from acute myeloid leukemia (AML), were shown to be enriched leukemic stem cells (LSC). We isolated the CD34+CD38− cell fraction from AML and compared their gene ...
Notably, this approach did not damage healthy early blood stem cells or immune cells in human and AML mouse models. When leukemia infiltrates the bone marrow, it generates CD38-positive abnormal ...
BN-CD38 eradicates acute myeloid leukemia (AML) by inducing the expression of its own therapeutic target and by expanding and redirecting autologous T-cells against AML blasts and leukemia stem cells.