Figure 1: Progression through the mammalian cell cycle. Figure 2 ... CDC6 localization is altered during quiescence. Cyclin A–CDK2-mediated CDC6 phosphorylation has been associated with CDC6 ...

p27 (also known as KIP1, and encoded by CDKN1B) is regulated by multiple signal transduction pathways in normal and malignant cells ... kinases reduces p27–CDK2 inhibition and transforms ...

Maintaining treatment with CDK4/6 inhibitors significantly suppresses the growth of breast cancer cells, even after drug resistance has developed, according to new research.