By acting on certain membrane sphingolipids, LAU-7b has also been shown to increase the confinement of cystic fibrosis transmembrane conductance regulator (CFTR) protein into lipid rafts ...

[1] These mutations are called gating mutations. The CFTR protein reaches the cell membrane but the channel does not open properly and chloride transport cannot occur (Figure 1d). Class IV ...

Zhengrong Yang, co-PI, capitalizing on the CFTR protein expression and purification expertise of their laboratory to offer recombinant CFTR proteins and cell/membrane biomass. Up to milligram ...

The first CF rat model, CFTR tm1sage (termed CFTR-/- or KO), was designed in collaboration with SAGE (now Horizon Discovery) and subsequently characterized at UAB and distributed to the CF community.

Allison Angell, the first person in the UK to have all of her major organs transplanted, has died aged 46—more than a decade ...

ALYFTREK™ is approved for patients 6 years and older with at least one responsive mutation, including 31 additional mutations not responsive to other CFTR modulator therapies - - In head-to-head ...

Vertex Announces US FDA Approval of ALYFTREK™, a Once-Daily Next-in-Class CFTR Modulator for the Treatment of Cystic Fibrosis - ALYFTREK™ is approved for patients 6 years and older with at ...