The investigators also found that scarring was minimal in mice injured on their first day of life ... “It pinpoints the timeline [of neonatal heart regeneration] in a manner that’s more precise than ...

New research highlights postnatal regeneration limits and ... Female CD1 mice were bred with Cx40eGFP/eGFP males for neonatal imaging and single-cell RNA sequencing (scRNA-seq) studies, while ...

These regulatory elements have been found in fruit flies, worms, and mice as well as the zebrafish. “We probably have them too,” said Ken Poss, Ph.D, the James B. Duke Distinguished Professor of ...

They secrete proteins and other molecules that, when released to tissues, can promote regeneration, acting “like a pharmacy that provides drugs for tissues to heal,” says Ke Cheng, a biomedical ...

They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing ...

They concluded that “aged cells are required for neonatal mouse heart regeneration and for Agrin-mediated cardiac repair in adult animals and provide insights into the essential role of Egr1 in ...

However, the protein is active during heart regeneration in zebrafish but not in mice suggesting that Hmga1 plays a key role in heart repair. Specifically, “Hmga1 was shown to reactivate ...

Kevin Watt, team leader of the Heart Regeneration and Disease Laboratory ... rapidly and has been shown to be effective already in mice, pigs and sheep. “The vision of our research is to develop ...