Subcellular mislocalization of checkpoint controllers is now surfacing as a mechanism of deregulating cell proliferation in cancer. Figure 1: Oncogene Her2/neu-initiated, Akt-mediated p21 Cip1 ...

indicating a role in NK cell exhaustion. IPE2, a negative regulator of IL-15 signaling, is increased under various conditions, inhibiting downstream AKT and Ral activation. The lack of TIPE2 in NK ...