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Cell论文:王一国/张惠杰团队发现调控胆固醇稳态的全新激素——Cholesin
该研究首次发现并命名了一种肠道激素——Cholesin(肠抑脂素),并揭示了Cholesin调控机体 胆固醇 稳态的作用和机制,Cholesin-GPR146信号轴介导了肠道胆固醇吸收和对肝脏胆固醇合成的抑制作用。这种新发现的激素有望成为治疗高胆固醇血症和动脉粥样硬化的有效药物。
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