Chemical cross-linking and X-ray studies performed with precisely defined chromatin fiber segments have lent support to the cross-linker model. DNA containing a repeated nucleosome-positioning ...

This experiment demonstrated that H2A, H2B, H3, and H4 form a discrete protein octamer, which is fully consistent with the presence of a repeating histone-containing unit in the chromatin fiber.

These modifications correlate with metabolic states, impacting chromatin accessibility and transcription. SCFAs, such as propionate and butyrate, derived from dietary fiber metabolism, serve as ...