This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

Chromatin modifications and nuclear organization are candidates for epigenetic marks — whether they fulfil the criterion of heritability and what mechanisms ensure their propagation is an area ...

Short-chain fatty acids influence gene regulation and chromatin accessibility, highlighting their role in colorectal cancer ...

Epigenetic modifiers, enzymes that catalyze covalent modifications on chromatin, play a pivotal role in establishing stable ...

Short-chain fatty acids (SCFAs) like propionate and butyrate are critical byproducts of dietary fiber digestion. These ...

Starting with the structure of the nucleosome and continuing with histone modifications, chromatin-remodeling complexes, silencing factors and more, a detailed and dynamic picture of chromosomal ...

We study all of the protein components of chromatin with an emphasis on understanding how multiple sources of variation function in concert or combination with each other. A major, but not exclusive ...

This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...

Lactylation is a reversible, covalent, post-translational modification of proteins. It occurs exclusively on lysine residues, where it influences protein structure, stability, localization, and ...

Epigenetic regulation relies on the dynamic modification of the two building blocks of chromatin: DNA and histone packaging proteins, to establish and maintain cell identity and fate. We develop and ...

Dr. Antonio Bedalov studies chromatin, the material that makes up the chromosomes of humans and other eukaryotes. He is learning how chromatin modifications influence important biological events ...

ERIL provides MSK researchers with state-of-the-art epigenetics research resources and services to study cancer-associated changes in chromatin accessibility, DNA methylation, and histone ...