Each of us has enough DNA to reach from here to the sun and back, more than 300 times. How is all of that DNA packaged so tightly into chromosomes and squeezed into a tiny nucleus? Histones are a ...

Alternatively, packing of sperm chromatin may serve to reprogram the paternal genome so that the appropriate genes from the father's chromosomes are expressed in the early embryo. Whereas most ...

Using advanced imaging, sensing, and analysis techniques, researchers discovered that transcriptional memory is encoded in 3D structural elements called nanoscale chromatin packing domains, which ...

gene expression in general. It was previously known that a particular type of RNA methylation known as m 6 A influences the ...

Major changes in gene expression underlie changes in cell state, including cell growth and a stress-resistant state called quiescence. Our scientists study how the organization of our chromatin - the ...

Proteins and DNA are the components of chromatin. Transcription factors control the density of this packing, and gene expression depends on DNA accessibility. The study's findings were released in ...

Toshio “Toshi” Tsukiyama studies how cells regulate chromatin, the packaging proteins responsible for compressing several feet of DNA ... can be harnessed to regulate cellular processes. Widespread ...