Thus, despite many refined and compelling studies, the structure of the 30-nm chromatin fiber—and, indeed, its very existence in vivo—remain open questions. The reader may feel overwhelmed by ...

The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA (Van Holde, 1988; Wolffe, 1999).

We specialize in high throughput top down liquid chromatography-mass spectrometry. This allows us to study chromatin biology with proteoform level specificity and observe quantitative changes to ...

We aim to trace metabolite signaling to chromatin, investigate how chromatin readers and other proteins interact with histone PTMs, and study the functional role of novel metabolite-derived histone ...