the E3 SUMO ligases PIAS1 and PIAS4 have an important role in the mammalian DDR pathway The ubiquitylation of histones H2A and H2AX at sites of DNA damage, which mediates the recruitment of ...

Senaparib is under clinical development by IMPACT Therapeutics and currently in Phase II for Solid Tumor. According to GlobalData, Phase II drugs for Solid Tumor have a 37% phase transition success ...

There is significant crosstalk between DNA damage response (DDR) pathways and innate immune pathways. Both the individual pathways and their interactions are key areas of interest for the ...

Here are some of the ways they are doing that: Cancer cells often acquire defects in their DDR pathways (or sometimes they are inherited e.g. BRCA1 and BRCA2), making them more reliant on other DNA ...

The study also provides direct evidence that the ATM-dependent DDR pathway is activated by a SSB of a defined DNA structure. Further, the UNC Charlotte study brings forth an intriguing inquiry on ...

Exploratory end points included outcomes relative to confirmation/mechanism of BAP1 loss, other DDR pathway dysfunction (cohort B), and other biomarkers that might predict response to PARPi.

In addition to DNA repair pathways, the DDR also encompasses cell cycle checkpoint control and cell death pathways. Several different DNA repair mechanisms exist to repair different subsets of DNA ...

To that point, studies show that up to 75% of solid tumors harbor DDR defects, making them prime candidates for therapies that target these defective repair pathways. Considering that solid tumors ...