During the DNA damage response (DDR), repair proteins such ... PIAS1 and PIAS4 have an important role in the mammalian DDR pathway The ubiquitylation of histones H2A and H2AX at sites of DNA ...

There is significant crosstalk between DNA damage response (DDR) pathways and innate immune pathways. Both the individual pathways and their interactions are key areas of interest for the ...

More than 60 years ago, we provided the first conclusive evidence that the fundamental cause of cancer is damage to our DNA. The DNA damage response is a series of pathways used by cells to repair ...

The DNA damage response (DDR) encompasses the intricate ... In addition to DNA repair pathways, the DDR also encompasses cell cycle checkpoint control and cell death pathways.

By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...

researchers demonstrate their use of plasmid-based SSB structures to examine APE1's critical role in DNA damage response (DDR) signaling pathways. Among other findings, the publication details ...

The principle of DNA damage response is already being exploited ... In certain cancer with mutations in DNA DDR pathways, inhibiting important nucleases can lead to cancer cell death.

Artios says it is significantly advanced over competition in the field of DNA Damage Response (DDR) therapeutics because ... By targeting this secondary pathway with drugs such DNA polymerase ...

This analysis has enabled a new level of molecular insight into the properties of these drugs whereby γH2AX foci analysis combined with predictive markers of the DDR pathway and cell cycle analysis ..

WD-induced MASLD triggered persistent activation of the DNA damage response (DDR) and its primary transcription factor, P53, ...