so histones bind with DNA very tightly. The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA ...

Histones proteins were selected early in evolution to transform DNA into chromatin filaments formed by many nucleosomes. The ...

Chromatin refers to proteins that help ... We've now zoomed in enough to see portions of the DNA strand. The DNA is wrapped around histones -- protein structures that are sometimes depicted ...

The mechanism of a peculiar type of heterochromatin, used by embryonic stem cells to silence 'parasitic' DNA-elements within the context of their highly dynamic pluripotent chromatin. Disclaimer ...

However, the process of DNA replication intrinsically disrupts nucleosomes ahead of the fork raising the question how chromatin structure is maintained across generations. Nucleosomes are re-assembled ...

The study examined how EV-DNA, through its association with histones, influences immune ... against metastasis and highlighted its unique chromatin structure. The findings demonstrated that ...

This allows us to study chromatin biology with proteoform level specificity and observe quantitative changes to reveal mechanisms of disease. Our laboratory works at the intersection of three fields: ...

to bind and cleave protein-unbound regions of DNA on chromatin. DNA bound to histones or other chromatin-bound proteins (e.g. transcription factors) may remain undigested. The uncut DNA is then ...

Histones are key proteins in the organization and regulation of DNA in all eukaryotic cells, i.e. cells in which DNA is ...

We are interested in how adenovirus manipulates host chromatin through protein VII and more broadly how DNA viruses use histones or histone-like proteins for dual function: to compact their genomes ...

Cell proteins called linker histones were discovered in the late 1800s. They have been known to influence genetic expression by, for example, providing structure, organization and folding of DNA ...