so histones bind with DNA very tightly. The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA ...

The DNA is then transfected into human cells that have been engineered to express a fusion protein consisting of a LacO binding domain and a factor called HJURP. The fusion protein binds to the LacO ...

The DNA of eukaryotes is compacted as chromatin, with the nucleosome representing ... as if Nr5a2 were throwing an anchor into the small turn of the DNA and pulling it away from the histones ...

He is learning how chromatin modifications influence important biological events within the cell’s nucleus and, in turn, how they affect development ... First, he studies how cells regulate the ...

DNA-containing genes are housed in chromatin, which can be opened or closed ... and thus greater ability to access and turn on the genes needed to quickly respond to stress." ...