How E3 ligases deal with such diverse substrates ... therefore creates diverse fragments that need to be cleaned up by an enzyme that combines specificity for amidated C termini with a flexibility ...

During ubiquitination, a group of enzymes called E3 ubiquitin ligases attach a small protein called ubiquitin to other proteins. This tagging, in turn, helps determine the fate of the targeted ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

E1 enzymes facilitate conjugation of ubiquitin and ubiquitin-like proteins through ... One early study revealed the kinetic basis for E3 ligase domains within the Nup358/RanBP2 nucleoporin, including ...

These small drug compounds destabilise proteins by bringing them into proximity with enzymes called E3 ubiquitin ligases that cause them to be broken down. The aim is to target rogue proteins ...