"That's also true of the NPC-like cells in high-grade glioma tumors." Moreover, the researchers discovered a new effect of the excessive methylation. They determined that this epigenetic change ...

In IDH-driven gliomas, the mutated IDH enzyme fosters the addition of methyl groups to the cells’ DNA. These chemical changes alter the expression of genes without modifying the underlying DNA ...

The present study emphasizes the importance of understanding the internal heterogeneity of pediatric gliomas for the development of personalized therapies. We have extensively characterized the global ...