Researchers at Case Western Reserve University School of Medicine have discovered how specific protein regions contribute to ...

So, the researchers tested estrogen that had been doctored so it could not enter cells and bind to nuclear receptors—a feat of chemical engineering performed by Dr. Jacob Geri, assistant professor of ...

The classic estrogen receptor signaling pathway occurs through the entry of estrogen into the cell, translocation to the nucleus, interaction with the nuclear estrogen receptor (ER) α or β ...

Figure 1: Nuclear receptor co-regulators modulate the transcriptional potential of estrogen receptor activated by estradiol, SERMs or growth factors. Although we have until now focused upon the AF ...

The VDR is a member of the steroid/hormone nuclear receptor superfamily that includes 48 ligand-activated transcription factors. [3] These factors bind to conserved elements in the promoters of ...

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So, the researchers tested estrogen that had been doctored so it could not enter cells and bind to nuclear receptors -- a feat of chemical engineering performed by Dr. Jacob Geri, assistant ...