Their earlier work revealed that FGF21 lowers blood glucose, regulates lipid metabolism, and increases insulin sensitivity by regulating the expression and secretion of adiponectin, a protein that ...

When the liver detects low levels of protein, it activates cells that produce FGF21 and release the hormone into the bloodstream. FGF21 is then carried to target cells (neurons) in the brain.

Based on our research, dual-functional biologics that engage adipocyte metabolism and gap junction activity are in development to improve ... The integration of the Connexin43 gap junction activator ...

Importantly, FGF19 and FGF21 are essential targets for drugs ... PPARA agonists can potentially improve lipid metabolism and reduce inflammation in NASH. Ongoing investigations into ACLY ...