Fibroblasts respond to tissue injury by producing and secreting ECM proteins to form the scar tissue at the wound site. 7 However, scientists need a better understanding of fibroblasts during wound ...

Fatty acid synthase, the enzyme responsible for fatty acid production in cells, may be a therapeutic target for IPF, a mouse ...

Ongoing work in our lab is focused on understanding cellular and molecular mechanisms governing variability in scar formation in inflamed tissues in different subsets of population. Specifically, the ...

Over time, increased scar tissue builds up in the intestinal ... macrophages are also in charge of activating specialized tissue-producing cells, called fibroblasts, to patch up wounds in the ...

Unlike other tissues, the heart cannot regenerate lost muscle cells. Instead, fibroblasts form scar tissue, preserving structural integrity but diminishing the heart’s ability to pump blood ...

Tackling the fibroblast cells that form scar tissue around tumours takes down a barrier that prevents or inhibits the effect of many therapies. There’s an increasing focus on using drugs to ...

The little nurses in the blood get started working on repairs with fibroblasts that create scar tissue. This scar tissue can form adhesions and restrictions because the repairs are like patch work ...