Resulting gaps are filled in by DNA polymerases; this reaction leaves a nick at or flanking the site of repair. An analogous process occurs during chromosomal DNA replication, whereby the 5’-RNA ...

Interestingly, these elements reside in introns, sections of DNA flanking exons that were traditionally deemed non-functional ...

Introns are DNA sequences flanking exons that have been referred to as "dark matter" of the genome because they were historically assumed to have no function. They are removed, or "spliced," out ...

The newly synthesized DNA (light blue) can then be joined with ... NHEJ and that uses short homology stretches (usually 2-3 bp) flanking the DSB can also be used (microhomology-mediated end ...

However, in fact a 'B6.129' congenic strain is developed with the disrupted 129-derived targeted allele and an unpredictable amount of flanking 129-derived DNA. Often after the targeted allele is ...

Exiqon LNA™ GapmeRs are 16 nucleotides long enriched with LNA™ in the flanking regions and DNA in a LNA™ free central gap - hence the name GapmeR. The LNA™-containing flanking regions confer nuclease ...