Thus, understanding differentiation pathways and functional attributes ... bound a consensus forkhead motif upstream of many Foxp3-regulated genes. Further work directly confirmed that Foxp3 ...

In this disorder, a mutation in the critical transcription factor gene forkhead box P3 (FOXP3) causes regulatory T cell dysfunction. The result is a collection of unwanted immune reactions appearing ...

Led by Dr. Donald Kohn and Katelyn Masiuk, the researchers engineered a 'viral vector' that would turn on the FoxP3 gene only in regulatory T cells -- and not in other types of cells. Disclaimer ...

The results highlight an important physiological function of PGAM in the differentiation and suppressive activity of Treg cells by regulating serine synthesis. This role is proposed to intersect with ...

1/IRF4 pathways. Raldh2, encoded by the Aldh1a2 gene, is expressed in intestinal ... RA drives the development of Tregs by activating Forkhead box P3 (Foxp3), the master transcription factor ...