The considerable progress made in the field of clinical neuro-oncology and the understanding of brain tumor biology is generating ... of the common genetic and molecular aberrations that underlie ...

Although the survival is generally dismal for glioblastoma patients, risk stratification and the identification of high-risk subgroups is important for prompt and aggressive management. The G1–G7 ...

However, if APE1 is inhibited, glioblastoma cells become highly sensitive to TMZ, even if the MMR pathway is inactive. Thus, APE1 represents the Achilles' heel (i.e., the most vulnerable spot ...

A study co-led by UCLA scientists has found targeting a protein called endocan and its related signaling pathway could be a ...

The technology will soon be tested in a clinical trial for people with glioblastoma. UCSF scientists have developed a "molecular GPS" to guide immune cells into the brain and kill tumors without ...

A recent study aimed to investigate the impact of lavender essential oil (LEO) and of its terpenic components on the ...

That is, endocan helps to define the molecular characteristics of this edge region. At the same time, the team also made the surprising discovery that endocan interacts with a receptor on glioblastoma ...

which provides us with added clarity with respect to paxalisib's potential registration pathway for the treatment of patients with NDU glioblastoma," commented Dr. John Friend, Kazia's CEO "We ...

He is also interested in exploring the interplay between kinase signaling and extracellular matrix remodeling in GBM. He uses advanced molecular techniques to characterize the signaling pathways in ...