On the basis of these results, the researchers propose a molecular stratification of glioblastoma consisting of four clinically relevant tumor subtypes—classical, mesenchymal, proneural and neural.

A key finding of the research is that the variability among glioblastoma cancer stem cells can be observed across a gradient between two cell subtypes. On one end is the developmental subtype ...

The patient-derived cell lines were generated by the lab of Peter Dirks, professor of surgery and molecular ... cell subtypes simultaneously could potentially make for a more effective ...

Although the survival is generally dismal for glioblastoma patients, risk stratification and the identification of high-risk subgroups is important for prompt and aggressive management. The G1–G7 ...

They discovered that gliocidin takes advantage of a specific weakness in the glioblastoma molecular machinery by indirectly blocking an enzyme known as inosine monophosphate dehydrogenase 2 (IMPDH2).

Craniopharyngiomas are brain tumors that negatively impact the hormonal function of the nearby pituitary. The tumor location often prevents necessary surgical intervention. Alternative pharmacological ...

The technology will soon be tested in a clinical trial for people with glioblastoma. UCSF scientists have developed a "molecular GPS" to guide immune cells into the brain and kill tumors without ...

UCSF scientists have developed a “molecular GPS” to guide immune cells into the brain and kill tumors without ... Working in mice, the scientists showed how the immune cells could eliminate a deadly ...