Early versions of these drugs caused drowsiness, so drug companies spent years trying to design more specific H1 antagonists to avoid this side effect. They finally succeeded in the late 1980s ...

This model paradigm was used to evaluate the most recently available H 1-receptor antagonist, desloratadine, and explains its efficacy in the treatment of allergic diseases.

For the antihistamine desloratadine, in vitro studies have revealed it to be a highly potent H 1-receptor antagonist and inhibitor of inflammatory mediators. Animal models with desloratadine have ...