Immune reconstitution inflammatory syndrome (IRIS) is a worsening of an HIV patient's clinical condition ... interactions with a G-protein-coupled receptor. 10 CNS IRIS in the setting of an ...

Taken together these data highlight that innate immune mediators ... including the role of HIV signaling through TLRs and other pattern recognition receptors and how this affects pDC functions ...

The main cells that HIV infects are those carrying a receptor molecule called CD4 on their surface. CD4 is found on immune cells, most particularly on T-helper cells and on macrophages. HIV gets ...

The treatment, which aims to provide immunity against various strains of the virus, produced an anti-HIV immune system response in tests on 393 people, a study in the Lancet found. It also ...

CCR5 is the most commonly used receptor by HIV-1 - the virus strain of HIV that ... The tests suggest 99% of Mr Castillejo's immune cells have been replaced by donor ones. But he still has ...

3T Biosciences has developed an immune response-guided approach for identifying pharmacologically active T cell receptors and their ... and infectious diseases—HIV and other viral diseases ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

They found that these unique immune responses are essential for rhesus CMV-based vaccines to be effective against SIV, the pathogen most used to model HIV/AIDS in nonhuman primates. "To develop an ...

that recognized tumor cells and activated an immune response. However, the receptors had one restriction: they could only recognize molecules that were on the surface of other cells. The system ...

2024 was another banner year for GLP-1 receptor agonists (GLP-1RAs) on multiple fronts. They continued to expand into new indications, and provide their... AI drives financings, approvals for APAC med ...

His work indicates that this effect is mediated by activation of dopamine receptors present on the macrophage surface ... counteract different types of neurological insults and boost CNS immune ...