A novel drug regimen tested for the first time by researchers at Fred Hutch Cancer Center has shown great promise in ...

Acute GVHD is a recognized complication of allogeneic ... of viable lymphocytes in the allograft recognizing the host HLA antigen type as foreign, resulting in a characteristic immune response.

High-resolution genomic HLA-typing was performed according to standard procedures. Animal experiments were approved by the local regulatory authorities according to German Federal Law. Flow ...

pointing out that better HLA typing is a major reason. However, a "big quantum leap" was the marked improvement in engraftment and the reduction of graft-versus-host disease (GVHD), he added ...

Research has shown that for each donor/recipient HLA mismatch, patient survival decreases significantly, primarily due to GvHD, and associated ... cyclophosphamide, the type of stem cell ...

[18] Measures to reduce GVHD risk would therefore include improvements in donor selection, improved HLA matching, as well as reduced intensity conditioning where possible. However, other trends ...