Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...

E. Huxley and J. Hanson (1954) observed changes in the sarcomeres as muscle tissue shortened. They observed that one zone of the repeated sarcomere arrangement, the "A band," remained relatively ...

Cardiomyopathy is a disease in which heart muscle is typically weakened or distorted ... corrects MyBP-C protein levels/expression in the sarcomere and dysfunctional contraction, while in vivo ...