we discuss the concept that hypoxia-associated genetic instability and faulty DNA repair might be a target for novel cancer therapies. A dynamic tumour microenvironment can not only promote ...

"However, it has been unknown, under hypoxia, whether and how HIF1α regulates IFN-γ induction and glycolysis in T cells." The UAB researchers found that HIF1α-glycolysis is indispensable for ...

During hypoxia, anaerobic glycolysis will be activated, which is facilitated by the lactate dehydrogenase (LDH) enzyme. This study aimed to analyze the LDH-specific activity in rat muscle and ...

"However, it has been unknown, under hypoxia, whether and how HIF1α regulates IFN-γ induction and glycolysis in T cells." The UAB researchers found that HIF1α-glycolysis is indispensable for ...