Induces potent and long-lasting immune responses to defined antigens or whole pathogens (particles), mainly through the ...

But despite their limitations, patient-derived organoids may be more reflective of their tissue of origin than other in vitro models, and so offer exciting new opportunities. For example ...

Organoids allow researchers to mimic complex tissues in vitro, reducing the need for animal models at early research stages. As organoid methods advance, researchers stretch their creativity and use ...

Bone marrow contains a heterogeneous mixture of mature and maturing precursors of blood cells, progenitor cells for myeloid and lymphoid lineages, and hematopoietic and mesenchymal stem cells.

The development of organoids has greatly advanced in the last decade with the realization that two-dimensional cellular samples in vitro cannot mimic the behavior of an entire organ. Today ...

The bank has since established more than 2,300 cancer cell lines and organoids — 3D clusters of cultured cells that mimic the complex behaviour of living organs — using tissue samples from ...

These investigations can be conducted in vitro using retinal organoids to quickly assess the retinal toxicity of novel compounds. Modeling retinal drug toxicity: Retinal organoids were tested for ...

Researchers have developed lab-generated lymph node–like organoids that, when transplanted into mice in place of lymph nodes that have been removed, drain fluid and connect to the animals’ original ...

Their research findings, published in the journal Nature Materials, mark a shift toward in vitro ... donors or lymphoma patients are cultured in these gel-like environments, the organoids support ...

AAV vector evaluation in vitro for retinal gene therapy Retinal organoids from Newcells have demonstrated the ability to serve as an instructive in vitro model for assessing novel retinal gene ...

Using a large-scale library of TC organoids they developed, the researchers performed comprehensive comparative analyses of chemo-sensitive and chemo-resistant cells. Their efforts shed light on ...