The mechanism of action of indomethacin, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Use lowest effective dose for shortest ...

May need to adjust dose of antidiabetic agents ... Toxic epidermal necrolysis possible with thalidomide. Concomitant indomethacin: may get false-negative on dexamethasone suppression test.