The transcription factor XBP1, which is activated by the ER transmembrane protein IRE1 (inositol-requiring transmembrane kinase/endonuclease 1), is an important component of the UPR. XBP1 induces ...

Indeed, activity of PERK (PRKR-like ER kinase) and IRE1 (inositol-requiring kinase 1) — key players in the unfolded protein response — was increased in mice on a high-fat diet, and these ...