The blood–brain barrier is the biggest challenge to the development of drugs that target the CNS. Most capillary beds leak plasma contents between and across endothelial cells by way of window-like ...

That's important, as Zolgensma is the world's most expensive drug, costing more than $2.1 million for a one-shot dose. Intrathecal delivery could kickstart sales of Zolgensma, which have taken a ...

Intrathecal anesthesia is commonly associated with nausea post delivery; [1,2,3 ... A known adverse effect of metronidazole (Flagyl) is a drug-drug reaction that occurs when metronidazole and ...

Novartis said it plans to share the Steer results with regulators, including the FDA, to seek approvals for OAV-101 IT. Grant said a submission is expected in the first half of 2025. Novartis had ...

Following FDA clearance of its investigational new drug (IND) application in December 2024 ... By focusing the treatment ...