Four studies examine this question, delving deeply into the role of the transcription factor Foxp3 in governing Treg differentiation and function. Tregs play essential roles in immune homeostasis ...

Bacchetta’s primary focus has been the rare autoimmune disorder IPEX syndrome, short for immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. In this disorder, a mutation in the ...

Led by Dr. Donald Kohn and Katelyn Masiuk, the researchers engineered a 'viral vector' that would turn on the FoxP3 gene only in regulatory T cells -- and not in other types of cells. Disclaimer ...