In 2010, a milestone was achieved when the first patient with cancer was treated with CAR-T-cell therapy ... to add the CAR gene to natural killer (NK) cells. “These cells are part of the ...

Unlike CAR-T cells, NK cells don’t need genetic modification to recognize a specific threat — they act broadly without customization. However, some NK companies, such as Fate Therapeutics and Cytovia ...

The idea that NK cells can distinguish ... years of experimental work to test its general predictions. I formulated the missing-self hypothesis for natural killer (NK) cell recognition in the ...

Unmodified natural killer (NK) cells work differently from the T-cells upon which CAR-T therapies ... Results from an early-stage safety trial in B-cell lymphoma have not shown any incidence ...

Now, researchers have identified a mechanism by which viral infection can lead to cachexia. In mice infected by a particular virus, killer T cells trigger the wasting of fat tissue and body weight, ...

The immune system responds to viral infections by introducing a complex interplay of immune cells and factors, whose goal is to eliminate the intruding pathogen. One such effector cell in the ...