A detail estimation of KRASG12D mut mCRC patients' characteristics and expected outcomes may be useful when planning future studies in this subgroup. The high prevalence of PI3K/PTEN/Akt pathway ...

The compound – called UA022 – targets the KRASG12D ... form of KRAS mutation in lung cancer, while G12D is found more commonly in other diseases like pancreatic and colorectal cancers.

Mutations in the adenomatous polyposis coli gene (APC) result in familial adenomatous polyposis (FAP), an autosomal dominant disorder that is marked by susceptibility to gastrointestinal tumours.