More than once-daily use was reported by 7.6% of losartan-plus-hydrochlorothiazide (Hyzaar) users, 5.5% of valsartan-plus-hydrochlorothiazide (Diovan HCT) users, and 4.2% of irbesartan-plus ...

In this 6-week, double-blind trial, 585 patients were randomized to losartan/ hydrochlorothiazide or losartan as monotherapy and titrated as needed at 2-week intervals to reach goal blood pressure ...