Interest in lysosomal storage diseases (LSDs ... these diseases could exceed US $1.9 billion in that year. Gaucher's disease is caused by a deficiency of glucocerebrosidase (GCR) and was the ...

The Lysosomal Metabolomics and pH Core’s overarching goal is to understand the mechanistic link between lysosomal activity and aging in Alzheimer’s Disease. To accomplish this, the core will support ...

These molecules, upregulated in cancer cells, are excreted through a surprising mechanism—lysosomal exocytosis. Even more fascinating is the intricate relationship between lysosomal exocytosis ...

In the study titled "Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles ... a major pathological marker of the disease. More importantly ...