South Korean biotech Prazer Therapeutics is creating and validating a breakthrough drug discovery and development platform based on targeted ... and lysosomal protein-degradation pathways for ...

(1) Degradation ... proteins are extracted and degraded by the ubiquitin-proteasome system. (3) A portion of mitochondria budding off as mitochondria-derived vesicles and fuse with lysosomes ...

Materials marked for degradation ... to lysosomes, where they are fully broken down. The transition from early endosomes to late endosomes involves a molecular "handoff," where the Rab5 protein ...